See which companies are making the headlines even before the bell rings.

Toyota (TM) – Toyota gained 2.2% in premarket trading, after announcing it would produce a record 800,000 vehicles in January. Toyota will increase its production to compensate for the parts shortages that caused earlier production to stop.

Vir Biotechnology (VIR) – Vir Biotechnology is rallying 4.3% in the premarket, putting it in position to rise for a fifth straight day. The drugmaker announced further data showing that its Covid-19 antibody therapy – developed in partnership with GlaxoSmithKline (GSK) – was effective against the omicron variant.

Eli Lilly (LLY) – The drugmaker raised its 2022 profit and revenue forecast ahead of today’s meeting with the investment community, noting that it is on track to meet its goal of delivering 20 new treatments in the 10-year period through 2023. Premarket, Lilly rose by 4.7%.

RR Donnelley (RRD) – RR Donnelley agreed to be acquired by Chatham Asset Management – the printing company’s top shareholder – for about $897 million. After determining Chatham’s offer was a superior proposal, Donnelley ended an earlier deal with Atlas Holdings to buyout the company. Stock fell by 2.8% during the premarket

Domino’s Pizza (DPZ) – Domino’s fell 2.1% in premarket trading after Barclays downgraded the stock to “underweight” from “equal weight.” Barclays stated that Domino’s was able to outperform the rest of the market due to its solid foundations and Covid headwinds, however it noted that these headwinds are now diminishing for the company’s competitors.

Regeneron Pharmaceuticals (REGN) – Regeneron was downgraded to “market perform” from “outperform” at Bernstein, which cites the risk to Regeneron’s best-selling eye drug Eylea from the future release of biosimilars. Regeneron lost 1.8% in premarket.

Six Flags (SIX) – The theme park operator’s stock rose 2.2% in the premarket after Goldman Sachs upgraded it to “buy” from “neutral,” noting resilient ticket pricing as well as guidance from Six Flags that Goldman considers conservative.

Hostess Brands (TWNK) – The maker of Twinkies and other snack foods was rated “buy” in new coverage at Citi, which said Hostess is exiting the pandemic in a strong position with innovation driving market share gains. The premarket saw Hostess rise 1.1%.

United Parcel Service (UPS) – UBS named the delivery service’s stock as a “top pick,” saying UPS should benefit from increased consumer spending and that it has a greater chance of margin expansion than its rivals. Premarket trading saw UPS rise 1.1%

CMC Materials (CCMP) – The advanced materials supplier agreed to be acquired by rival Entegris (ENTG) in a cash-and-stock deal. The transaction’s value is $197.53 for each CMC share, as compared to CMC’s Tuesday closing price of $145.97. Premarket, Entegris declined 3%

Bloomin’ Brands (BLMN) – The Outback Steakhouse parent surged 5.3% in premarket trading after Jefferies added the stock to its “franchise picks” list, saying the company was positioned to benefit from positive structural changes in the casual dining category.