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Data suggests mRNA booster dose generates stronger antibody response after J&J shot

by Mike Robinson

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© Reuters. FILE PHOTO: Vials labelled “COVID-19 Coronavirus Vaccine” and sryinge are seen in front of displayed Johnson&Johnson logo in this illustration taken, February 9, 2021. REUTERS/Dado Ruvic/Illustration

(Reuters) – People who received Johnson & Johnson (NYSE:)’s COVID-19 vaccine will have a stronger neutralizing antibody response if they get an mRNA shot as the second dose, Axios reported https://www.axios.com/coronavirus-vaccine-booster-fda-mix-match-data-2593a8db-6b5e-4333-95e2-4064b2433e42.html?utm_source=twitter&utm_medium=social&utm_campaign=onhrs on Tuesday, citing a person who has seen data collected by the U.S. National Institutes of Health (NIH).

J&J has asked the U.S. Food and Drug Administration (FDA) to approve a shot of its own single-dose vaccine as the booster dose. On Friday, FDA advisers will consider this need.

Axios stated that Friday’s mix-and-match data will be presented by the NIH to FDA panels.

The report stated that there were limitations to data from the NIH. According to the report, neutralizing antibodies prevent virus replication in cells. It is not possible to predict how long this response will be effective.

The NIH, FDA and J&J did not immediately respond to Reuters’ requests for comment.

Two-dose vaccines made by Pfizer Inc (NYSE:), and BioNTech, its German Partner Moderna (NASDAQ) Inc utilizes the mRNA technology.

Experts from the outside will discuss Friday’s need to administer an extra Moderna vaccine dose.

FDA scientists have stated that Moderna did not meet all criteria for the FDA to allow booster doses. This could be because Moderna’s effectiveness has remained high.

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